Augmenting Effect of Serotonin on the Voltage-Dependent Ca2+ Current and Subsequently Activated K+ Current in Aplysia Neurons
نویسندگان
چکیده
منابع مشابه
Zn2+ blocks the voltage activated calcium current of Aplysia neurons.
We have investigated the effect of Zn2+ on voltage-activated calcium currents of Aplysia neurons, using conventional two-electrode voltage-clamp techniques. The peak of these currents was reversibly reduced by Zn2+ (50% reduction at 3.75 mM; total block at 20 mM), while the current-voltage relation and the activation and inactivation curves were shifted to depolarized voltages. The effects of Z...
متن کاملLead inhibits the voltage-activated calcium current of Aplysia neurons.
Lead is a potent and reversible inhibitor of the voltage-dependent calcium current of Aplysia neurons in a concentration range (1-1000 microM) similar to that which elicits toxic effects in man. The threshold for inhibition is 1 microM and the dissociation constant about 90 microM. The inhibition is due to reduction of the peak current amplitude, and not due to alteration of the voltage depende...
متن کاملModulation of a steady-state Ca2+-activated, K+ current in tail sensory neurons of Aplysia: role of serotonin and cAMP.
1. The modulation of membrane currents by serotonin (5-HT) was studied in isolated clusters of tail sensory neurons. Serotonin was applied by micropressure ejection onto the somata of sensory neurons voltage-clamped at fixed holding potentials. The range of holding potentials tested in this study was selected to produce a steady-state Ca2+-activated K+ current (IK,Ca). Serotonin induced an inwa...
متن کاملAnalysis of the modulation by serotonin of a voltage-dependent potassium current in sensory neurons of Aplysia.
Potassium currents in pleural sensory neurons of Aplysia were studied under control conditions and in the presence of serotonin (5-HT). Using pharmacological techniques we isolated a current that we refer to as IK,V. Although it is not known whether IK,V represents a distinct type of membrane channel, we described its properties using a Hodgkin-Huxley type model. The effects of 5-HT on IK,V wer...
متن کاملProlonged activation of Ca2+-activated K+ current contributes to the long-lasting refractory period of Aplysia bag cell neurons.
Stimulation of the bag cell neurons of Aplysia activates several biochemical pathways, including protein kinase C (PKC), and alters their excitability for many hours. After an approximately 30 min afterdischarge, these neurons enter an approximately 18 hr inhibited state during which additional stimulation fails to evoke discharges. In vivo, this refractory period limits the frequency of reprod...
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ژورنال
عنوان ژورنال: The Tohoku Journal of Experimental Medicine
سال: 2007
ISSN: 0040-8727,1349-3329
DOI: 10.1620/tjem.211.31